Background: Cerebral palsy is a heterogeneous disorder resulting from a non-progressive damage to the developing brain that cause mostly a variable degree of chronic motor disability and developmental abnormalities during early childhood including delayed speech and motor development. Because of the heterogeneous nature of the condition and variable severity and presentations, patients are generally treated with an individualized treatment plans that provides a combination of interventions including treatment of spasticity with muscle relaxants and physical therapy. Patients with severe condition can have significant disability, while patients with less severe disorder experience delay in motor developments and learning difficulties. The aim of this paper is to describe retrospectively our experience with use of nandrolone decanoate (ND) and pyritinol in children with a less severe form of cerebral palsy with aim of improving motor functions and learning abilities.
Patients and Methods: Five patients (3 males and 2 girls) with cerebral palsy presenting mainly with spasticity, hyperreflexia and delayed speech and motor development. The patients were treated with intermittent low dose intra-muscular (i.m) injections of ND (12.5 mg for children under 2 years, 25 mg for the older child) with the aim of improving their delayed motor development. Pyritinol was used in the one patient in addition to ND with aim of improving his learning abilities. Estimation of the bone age was made using radiographs of the left wrist before the injection and 2 weeks after each injection. The patient was monitored weekly for the development of hypertension and sign of virilization. All the patients had normal or delayed bone age before treatment.
Results: The use of nandrolone decanoate intramuscular injections and pyritinol was associated with dramatic effect on the motor development and learning abilities respectively without the occurrence of any adverse effects. Mild advancement of bone age was noticed only in one patient.
Conclusion: nandrolone decanoate and pyritinol can be useful in the management of cerebral palsy.
Keywords: Cerebral palsy, Development, Nandrolone, Pyritinol.
Introduction
Cerebral palsy is a heterogeneous disorder resulting from a non-progressive damage to the developing brain that cause mostly a variable degree of chronic motor disability and developmental abnormalities during early childhood including delayed speech and motor development. Because of the heterogeneous nature of the condition and variable severity and presentations, patients are generally treated with an individualized treatment plans that provides a combination of interventions including treatment of spasticity with muscle relaxants and physical therapy. Patients with severe condition can have significant disability, while patients with less severe disorder experience delay in motor developments and learning difficulties [1-3]. The aim of this paper is to describe retrospectively our experience with use of nandrolone decanoate (ND) and pyritinol in children with a less severe form of cerebral palsy with aim of improving motor functions and learning abilities.
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